chapter  52
The Blue Medical 50% TEMPO coronary stent: preclinical studies and the first clinical pilot trial Xiaoshun Liu, Yanming Huang and Ivan De Scheerder
Pages 13

The success of coronary stenting is plagued by high restenosis rates of up to 67%, depending on issues, such as patient and lesion related factors, the indication and technique of stent deployment, and others.1-3 In-stent restenosis is considered as being a local increase of the biological response to vessel wall injury, which involves a cascade of cellular and molecular responses. Among others, oxygen free radicals, induced by the inflammatory response, induced by the implantation of a foreign body may play an important role in the formation of the neointimal hyperplasia and in-stent restenois. Free radical driven reactions, such as oxidative phosphorylation, lipid peroxidation, and DNA scission can be toxic for the cell function, resulting in cell necrosis.