chapter  12
31 Pages

Polymer Beads in Biomedical Chromatography

I. INTRODUCTION Polymeric microspheres have attracted significant attention in the various applications such as affinity chromatography, high-performance liquid chromatography (HPLC), enzyme immobilization, drug delivery, and cell culturing. The size, polydispersity, porosity properties, and functional groups are important factors affecting the overall performance of the particles in biomedical applications. The polymeric microspheres from nanometer to millimeter scale are obtained by applying different processes including suspension, emulsion, dispersion, and polymerization. The polymerization methods for producing polymer beads with different size and surface properties are reviewed below.