chapter  4
30 Pages

## Twin-Screw Extrusion and Screw Design

For those unacquainted with twin-screw extruders (TSEs) there is cause for

cautious optimism in knowing that the use of this well proven and versatile

tool is within grasp to make a better, more repeatable, ‘‘good-manufacturing-

practice’’ (GMP) product. However, given the peculiar nature of pharmaceut-

ical-grade materials and processes, potential users should also exercise caution

about importing solutions that worked for plastics and rubber, which served as

the preamble for most of this work.