Human Experimental Models of Virus Infection and Asthma
Vaccination against smallpox and the eradication of the disease still stands as monumental achievements. In addition to its direct beneﬁts in the prevention of a lethal disease, the method employed directed the thinking of later investigators to the use of volunteers in medical research. It is now more than 200 years since Jenner conducted his ﬁrst experiments with vaccination. In recent years experimental viral disease programs in volunteers have been extended and reﬁned, yielding many advances in knowledge of the epidemiology, transmission, and clinical manifestations of such diseases.