chapter  36
28 Pages

Mechanistic Principles of Photodynamic Therapy

Photodynamic therapy (PDT) exploits the biological consequences of localized oxidative damage inflicted by photodynamic processes. A schematic outline of the major steps that lead to tumor destruction by PDT is given in Figure 36.1. Three critical elements are required for the initial photodynamic processes to occur: a drug that can be activated by light (a photosensitizer), light, and oxygen.