chapter  11
14 Pages

Nutrients as Modulators of Immune Dysfunction and Dyslipidemia in AIDS

Acquired immunodeficiency syndrome (AIDS) is characterized by infection with human immunodeficiency virus (HIV) and progressive depletion of CD4+(helper) T cells, leading to opportunistic infections and malignancies (1). In addition to CD4+ cell loss, HIV-infected patients manifest impairment of immune response, affecting both CD4+ and CD8+ T-cell subsets, that resembles an anergic state of immune dysfunction (2). These defective immunological responses include decreased interleukin-2 (IL-2) secretion and unresponsiveness to recall antigens or stimulation through the CD3/TCR complex (3).