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Multiple Sclerosis

DOI link for Multiple Sclerosis

Multiple Sclerosis book

Tissue Destruction and Repair

Multiple Sclerosis

DOI link for Multiple Sclerosis

Multiple Sclerosis book

Tissue Destruction and Repair

Edited ByKenneth Johnson, Ludwig Kappos, Jurg Kesselring, EW Radü

Edition 1st Edition

First Published 2001

eBook Published 25 January 2001

Pub. location London

Imprint CRC Press

DOI https://doi.org/10.3109/9780203212974

Pages 360 pages

eBook ISBN 9780429218064

SubjectsMedicine, Dentistry, Nursing & Allied Health

Get Citation

Johnson, K. (Ed.), Kappos, L. (Ed.), Kesselring, J. (Ed.), Radü, E. (Ed.). (2001). Multiple Sclerosis. London: CRC Press, https://doi.org/10.3109/9780203212974

This volume includes the latest developments, both in research and the clinic. Published in Association with the European and American Committees for Treatment and Research in Multiple Sclerosis (ECTRIMS & ACTRIMS). Following on from three previous books in the Frontiers of Multiple Sclerosis series the editors have selected a range of further

TABLE OF CONTENTS

part 1|2 pages

Neuronal control of the immune response in the CNS: implications on neuronal cell death and survival

ByHarald Neumann

chapter 1|9 pages

Neuronal control of the immune response in the CNS: implications on neuronal cell death and survival

chapter 2|16 pages

Oligodendrocyte susceptibility to immune-mediated injury

ByJack Antel

chapter 3|10 pages

Strategies for repair in MS: the potential role of glial-cell transplantation

ByIan D Duncan

chapter 4|10 pages

Growth factors, lesion repair and myelin regeneration

ByHenry deF Webster

chapter 5|5 pages

Effects of BDNF and NGF on cytokine expression in immune cells

part |2 pages

PART II In vivo assessment of tissue destruction and its consequences

chapter 6|24 pages

Magnetization transfer imaging in multiple sclerosis

ByMassimo Filippi, Joseph C McGowan, Carla Tortorella

chapter 7|11 pages

Clinicopathological correlations for black holes: an MRI marker for axonal loss?

chapter 8|17 pages

Magnetic resonance spectroscopy of multiple sclerosis: imaging axonal damage

chapter 9|9 pages

Measurement of atrophy

chapter 10|17 pages

Quantification of MS lesion evolution in a serial MRI study

chapter 11|9 pages

Functional imaging

chapter 12|8 pages

A 1-year serial clinical and MRI study of primary progressive multiple sclerosis

part |2 pages

PART II In vivo assessment of tissue destruction and its consequences

chapter 13|20 pages

Immunological parameters in blood as surrogate markers in multiple sclerosis

chapter 14|12 pages

Cerebrospinal fluid markers of tissue destruction and repair in multiple sclerosis

chapter 15|10 pages

Myelin products: myelin basic protein like material in cerebrospinal fluid and urine in multiple sclerosis

chapter 16|7 pages

In vivo assessment of tissue destruction and repair: the role of neurophysiology

part |2 pages

PART III MS fatigue

chapter 17|7 pages

Pathophysiology of fatigue in multiple sclerosis

ByUlrich Roelcke

chapter 18|10 pages

Assessment and treatment of fatigue in multiple sclerosis

ByLauren B Krupp

part |2 pages

PART IV New immunologic concepts and their therapeutic consequences

chapter 19|12 pages

T-cell autoreactivity against self glycosphingolipids in multiple sclerosis

chapter 20|18 pages

Degeneracy in T-cell antigen recognition

ByBernhard Hemmer, Norbert Sommer

chapter 21|7 pages

T-cell apoptosis in the nervous system and therapeutic implications

ByRalf Gold, Klaus Viktor Toyka, Hans Lassmann

chapter 22|8 pages

IL-12: immunological staging of multiple sclerosis and measure of response to therapy

chapter 23|10 pages

Interferon-β-1b in inhibits interleukin-12 production in peripheral blood mononuclear cells through an interleukin-10 dependent mechanism

chapter 24|14 pages

T-cell vaccination and antigen-driven immunotherapy for multiple sclerosis

ByAriel Miller, Jingwu Zhang

chapter 25|12 pages

Specific immunomodulation in multiple sclerosis by altered peptide ligands

ByRoland Martin

part |2 pages

PART V Treatment of relapses

chapter 26|11 pages

Treatment of relapses: update on steroids, mode of action, optimal route and dosage

chapter 27|10 pages

Plasma exchange for severe attacks of demyelinating disease of the central nervous system

part |2 pages

PART VI Modern concepts of therapeutic immunosuppression

chapter 28|11 pages

Intensive immunosuppression in multiple sclerosis: efficacy versus toxicity

ByRichard E Gonsette

chapter 29|7 pages

The role of intensive immunosuppression in multiple sclerosis: prospects of combinations

chapter 30|12 pages

High-dose immunosuppression and peripheral stem cell transplantation in multiple sclerosis: preclinical experience and problems

chapter 31|10 pages

Autologous stem cell transplantation in multiple sclerosis: preliminary clinical results and future activities

part |2 pages

PART VII Update on therapeutic trials

chapter 32|7 pages

Improvement of magnetization transfer ratio in new gadolinium-enhanced lesions detected before and during therapy with interferon-β-1a

chapter 33|6 pages

Longitudinal prospective evaluation of treatment effects, MRI and neutralizing antibodies in multiple sclerosis patients treated long-term with interferon-β-1b (Betaseron®)

chapter 34|5 pages

Therapy-induced antibodies against interferon-β-1a and interferon-β-1b in patients with multiple sclerosis

chapter 35|5 pages

Intravenous immunoglobulin in childbirth-related exacerbations of multiple sclerosis

chapter 36|7 pages

The European Study on Enzyme Therapy in Multiple Sclerosis (ESEMS): results of a multicentre, randomized, double-blind, placebo-controlled study

chapter 37|3 pages

A Phase I trial of solubilized DR2: MBP(84-102) (AG284) in multiple sclerosis

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