Colorectal Cancer | A Clinical Guide to Therapy | Harry Bleiberg, Nanc

Book

Colorectal Cancer

ABSTRACT

Researchers have forged new understanding of colorectal cancer in recent years. That developing knowledge has led to new treatment methodologies and an increase in early detection of the disease. This text focuses on the practical application of the latest advances, emphasizing the therapeutic strategies that have now evolved. An international team

TABLE OF CONTENTS

part |2 pages

Part 1 Background and Epidemiology

chapter 1|8 pages

Biology of colorectal cancer: An overview of genetic factors Marc J Abramowicz

chapter 2|20 pages

Recent developments in the epidemiology of colorectal cancer Peter Boyle, Maria Elena Leon

part |2 pages

Part 2 Prevention and Screening

chapter 3|6 pages

Hemoccult as an approach to colorectal cancer screening Jean Faivre, Anne-Marie Benhamiche

chapter 4|8 pages

Screening colonoscopy Ann G Zauber, Sidney J Winawer

chapter 5|6 pages

Chemoprevention of colorectal cancer Robert Benamouzig

part |2 pages

Part 3 Pathology and Prognostic Factors

chapter 6|18 pages

Pathology of colorectal cancer Paul Hermanek

chapter 7|8 pages

Sentinel lymph-node mapping in colorectal cancer Sukamal Saha, Anton Bilchik, David Wiese

chapter 8|10 pages

Postoperative histopathological evaluation: Implications for prognosis Fred T Bosman

part |2 pages

Part 4 Management of Localized Disease

chapter 9|14 pages

Surgery for colon cancer Clare Adams, John W Fielding, Dion G Morton

chapter 10|10 pages

Laparoscopic left colectomy for cancer Guy-Bernard Cadière, Jacques M Himpens

chapter 11|10 pages

Minimal invasive surgery for colon cancer: Where do we stand? Jose I Restrepo, Heidi Nelson

chapter 12|8 pages

Systemic adjuvant therapy of colon cancer Rachel Midgley

chapter 13|4 pages

Adjuvant treatment in Dukes B2 colon cancer: No Charles Erlichman, Daniel J Sargent

chapter 14|8 pages

Adjuvant treatment in Dukes B2 colon cancer: Yes

chapter 15|8 pages

Adjuvant intraportal treatment Roberto F Labianca, Giordano D Beretta, M Adelaide Pessi

chapter 16|6 pages

Adjuvant intraperitoneal chemotherapy Christophe Penna, Robert Malafosse, Bernard Nordlinger

chapter 17|12 pages

Management of peritoneal surface malignancy from colorectal cancer: The surgeon’s role Paul H Sugarbaker

chapter 18|12 pages

Surgery for rectal cancer Rudolf Raab, Hans-Joachim Meyer, Uwe Werner

chapter 19|8 pages

Total mesorectal excision: A quality-controlled approach to rectal cancer surgery Thomas Cecil, Brendan J Moran, Richard J Heald

chapter 20|12 pages

Conservative treatment in rectal cancer Philippe Lasser, Ali Goharin

chapter 21|24 pages

Treatment of locally advanced primary and locally recurrent colorectal cancer Roger Dozois, Steven Schild, John Pemberton, Tonia Young-Fadok

chapter 22|10 pages

Radiotherapy for rectal cancer: The European approach Lars Påhlman, Bengt Glimelius

chapter 23|10 pages

Radiotherapy for rectal cancer: The US approach Harvey Mamon, Christopher Willett

chapter 24|8 pages

Radio-chemotherapy in rectal cancer: When and for which patients? Jean-François Bosset, Georges Mantion, Philippe Maingon

chapter 25|6 pages

The future of radiotherapy in rectal carcinoma Jean Bourhis, Antoine Lusinchi, François Eschwège

part |2 pages

Part 5 Follow-up of Colorectal Cancer

chapter 26|10 pages

Which follow-up for colorectal cancer? Perhaps none John MA Northover

chapter 27|6 pages

The case for CEA screening John S Macdonald

chapter 28|14 pages

New methods for early detection of disease recurrence Roland Hustinx, Frédéric Daenen, Robert F Dondelinger, Pierre Rigo

part |2 pages

Part 6 Treatment of Other Sites

chapter 29|12 pages

Cancer of the appendix and pseudomyxoma peritonei syndrome Paul H Sugarbaker

chapter 30|12 pages

Treatment of anal canal carcinoma Didier Peiffert

part |2 pages

Part 7 Management of Metastatic Disease

chapter 31|12 pages

Resection of liver metastases Matthias Lorenz, Stefan Heinrich

chapter 32|4 pages

Surgery of lung and brain metastases Christopher Penna, Robert Malafosse, Bernard Nordlinger

chapter 33|14 pages

Ablative technique for liver metastases Steven N Hochwald, Yuman Fong

chapter 34|6 pages

Neoadjuvant treatment of colorectal liver metastases allowing resection René Adam, Eli Avisar, Francis Kunstlinger, Francis Lévi, Henri Bismuth

chapter 35|8 pages

Nancy Kemeny, Don S Dizon

chapter 36|8 pages

Locoregional chemotherapy for metastatic colorectal cancer to the liver Don S Dizon, Nancy Kemeny

chapter 37|16 pages

Predictive markers in the treatment of colorectal cancer Cynthia Gail Leichman

chapter 38|8 pages

Mechanism of action of 5-ﬂuorouracil in colorectal cancer treatment Alberto F Sobrero

chapter 39|20 pages

From the laboratory to the clinic: The limitations of rationally designed ﬂuoropyrimidine-based therapy and the problem of apoptosis-impaired cancer cells Jean L Grem

chapter 40|12 pages

Pharmacogenetics of colorectal cancer chemotherapy drugs: Implications for the pharmacokinetic adjustment of chemotherapy Erick Gamelin, Michèle Boisdron-Celle

chapter 41|10 pages

The Mayo Clinic/NCCTG (North Central Cancer Treatment Group) regimen of 5-ﬂuorouracil and leucovorin: Origins, activity, and future applications Richard M Goldberg, Daniel J Sargent

chapter 42|12 pages

The Roswell Park regimen: Weekly 5-FU and high-dose leucovorin for colon cancer Peter C Enzinger, Robert J Mayer

chapter 43|10 pages

Infusional 5-FU: The 24-hour weekly approach Clause-Henning Köhne

chapter 44|4 pages

Infusional 5-ﬂuorouracil: The bimonthly approach Aimery de Gramont, Christophe Louvet, for the GERCOR (Oncology Multidiscplinary Research Group)

chapter 45|6 pages

Infusional 5-FU in the treatment of metastatic colorectal cancer: The 48-hour weekly approach Andrés Cervantes, Eduardo Díaz-Rubio, Enrique Aranda, on behalf of the Spanish Group for Gastrointestinal Tumor Therapy (TTD)

chapter 46|10 pages

Infusional 5-ﬂuorouracil: Protracted infusion Norwood R Anderson, Jacob J Lokich

chapter 47|8 pages

Oral ﬂuoropyrimidines in colorectal neoplasia Melanie B Thomas, Paulo M Hoff

chapter 48|8 pages

5-FU in combination with DPD inhibitors Robert B Diasio

chapter 49|8 pages

Irinotecan: Mechanism of action Udo Vanhoefer, Youcef M Rutsum

chapter 50|12 pages

Oxaliplatin: Mechanism of action and preclinical activity Eric Raymond, Stephen Chaney, Esteban Cvitkovic

chapter 51|12 pages

Raltitrexed and the new thymidylate synthase inhibitors Hugo ER Ford, David Cunningham

chapter 52|22 pages

New combinations in colorectal cancer François Goldwasser, Esteban Cvitkovic, Patrice Hérait

chapter 53|10 pages

Irinotecan: Combination chemotherapy Hansjochen Wilke, Udo Vanhoefer, Wolf Achterrath

chapter 54|8 pages

Bimonthly leucovorin–5-ﬂuorouracil with oxaliplatin or irinotecan: The FOLFOX and FOLFIRI Frédérique Maindrault-Goebel, Pascal Artru, Marcel Krulik, for the GERCOR (Oncology Multidisciplinary Research Group)

chapter 55|18 pages

Chronomodulation of chemotherapy against metastatic colorectal cancer Francis Lévi, Sylvie Giacchetti

chapter 56|6 pages

Which treatment in ﬁrst line? The US approach Michael J O’Connell

chapter 57|10 pages

Which treatment in ﬁrst line? The European approach

chapter 58|10 pages

Treatment strategies after ﬁrst-line therapy Eric Van Cutsem, Chris Verslype

chapter 59|8 pages

Drug development in colorectal cancer: Viewpoint of the United States cooperative groups David L Grinblatt, Richard L Schilsky

chapter 60|6 pages

Drug development in colorectal cancer: Viewpoint of the European cooperative groups Jacques Wils

chapter 61|8 pages

New chemotherapy approaches in colorectal cancer Richard M Goldberg, Charles Erlichman

part |2 pages

Part 8 New Approaches to Treatment

chapter 62|10 pages

New treatment concepts Guy A Chung-Faye, Ming-Jen Chen, David J Kerr

chapter 63|12 pages

Gene therapy Paul Jacobs, Vincent Richard, Diamon Gangji, Thierry Velu

chapter 64|10 pages

Vaccine therapy for colorectal cancer John L Marshall, Evelyn S Fox

part |2 pages

Part 9 Critical Issues in Colorectal Cancer

chapter 65|10 pages

Quality of life and methodology in colorectal cancer studies Bengt Glimelius

chapter 66|8 pages

Cost assessments in colorectal cancer Niels Neymark

chapter 67|12 pages

Critical issues in colorectal cancer randomized trials and meta-analysis Jean-Pierre Pignon, Marc Buyse, Pascal Piedbois