6 Pages


Oestrogen has important effects on skeletal

health throughout childhood, adolescence,

and adult life. In particular, the loss of

oestrogen at the menopause results in

accelerated bone loss and is a major

pathogenetic factor in postmenopausal

osteoporosis. Although it is well documented

that oestrogen replacement at the menopause

prevents bone loss, evidence for anti-fracture

efficacy is based mainly on observational

studies and is less robust than that now

available for several other interventions,

including alendronate, raloxifene, and