chapter
6 Pages

References

Oestrogen has important effects on skeletal

health throughout childhood, adolescence,

and adult life. In particular, the loss of

oestrogen at the menopause results in

accelerated bone loss and is a major

pathogenetic factor in postmenopausal

osteoporosis. Although it is well documented

that oestrogen replacement at the menopause

prevents bone loss, evidence for anti-fracture

efficacy is based mainly on observational

studies and is less robust than that now

available for several other interventions,

including alendronate, raloxifene, and

risedronate.