chapter  7
11 Pages

Hormone replacement therapy and vascular flow

ByMichael S Marsh

CHD in postmenopausal women.

Synthetic progestogens bind to

progesterone receptors but exhibit differing

degrees of androgenicity. In general, C-21

steroids derived from progesterone have a high

affinity for progesterone receptors and have

minimal androgenic activity, whereas

progestogens derived from testosterone and

19-nortestosterone have more androgenic

activity. It is likely that the cardiovascular

effects of different progestogens are in part

related to their differing androgenicity.