chapter  5
14 Pages

Cardiovascular Disease in the Insulin-Resistant, Atherosclerosis-Prone JCR :LA-cp Rat

WithJ.C. Russell and S.E. Kelly

Driven by the increasing incidence of obesity in western societies, the insulin resistance syndrome is rapidly becoming a major cause of morbidity and mortality. The primary factor in this is its prominent association with cardiovascular disease. However, the nature of the underlying mechanisms leading to end-stage myocardial and other ischemic disease is still to date unclear. The clarification of these mechanisms remains a necessary step in the effective prevention and treatment of one of the primary determinants of cardiovascular disease.