Cardiovascular Disease in the Insulin-Resistant, Atherosclerosis-Prone JCR :LA-cp Rat
Driven by the increasing incidence of obesity in western societies, the insulin resistance syndrome is rapidly becoming a major cause of morbidity and mortality. The primary factor in this is its prominent association with cardiovascular disease. However, the nature of the underlying mechanisms leading to end-stage myocardial and other ischemic disease is still to date unclear. The clariﬁcation of these mechanisms remains a necessary step in the effective prevention and treatment of one of the primary determinants of cardiovascular disease.