The growing concept of being able to protect neurons from damaging stimuli, or being able to rescue them from actively executing a cell death program, carries with it the requirement of being able to deliver the appropriate drug or agent to the target cells. In the eye, this means being able to apply an effective dose of an agent to the retina and optic nerve. In some cases, it may also mean that the drug be applied continuously or for a sustained period of time in order to achieve a therapeutic effect. This chapter describes methods that have been used by various laboratories to deliver agents, most notably small pharmacological molecules, successfully. Each method has its advantages and disadvantages, which will be discussed.