chapter  3
8 Pages

Intraocular Pressure Elevation: Vein Cauterization

BySansar C. Sharma

Glaucoma is an optic neuropathy in which damage primarily occurs to the optic nerve axons and the retinal ganglion cells. The death of neurons and damage to the axons is related to the increase in intraocular pressure. The need to develop a suitable animal model stems from the fact that experimentation on monkeys (the ideal animal to study progression of a pathology) is expensive. In an ideal situation, an animal model should provide results that are consistent and cost effective. Our model is based on the concept that obstructing the outflow of aqueous humor would mimic the disease process, thereby providing conditions suitable for studying the effect of various neuroprotective agents.