chapter  5
10 Pages

Biotransformation of drugs in man: characterization and prediction

ByD. D. Breimer

Individual patients show a wide variation in response to the same dose of a drug. Much of this interindividual variability in drug response can be explained by pharmacokinetic factors, for example absorption, distribution, metabolism and excretion. The rate at which these processes occur and which consequently determines the concentration time-course of a drug at the receptor sites is influenced by many factors pertaining to the drug and its dosage form, to pathophysiological circumstances, to genetic variables especially those determining the rate of drug metabolism and to the effects caused by other drugs taken concurrently.