ABSTRACT
Resin-based dental sealants and composites contain bisphenol A-glycidyl methacrylate, a bisphenol A (BPA) derivative. The potential exists for human exposure after sealant placement. Therefore the authors investigated the changes in the BPA concentration in saliva before and after restorations with sealant resin. The authors examined salivary BPA measurements (in micrograms per liter) before and after placement of clinically appropriate amounts of one of two sealants for 35 adults (18 males and 17 females) using ELISA kit. We detected BPA in most of the tested samples. Salivary BPA concentrations in pre-treatment or baseline samples ranged from 0.000 to 3.300 μg/ℓ and salivary BPA concentrations in immediately post-treatment samples ranged from 0.002 to 8.147 ng/mℓ. There was no significant difference between pre-treatment and post-treatment in BPA concentra-tion of saliva. Though the findings were in the direction hypothesized, the authors did not observe a statistically significant association between dental sealant restoration and higher salivary BPA concentrations. Additional studies are needed to determine the extent of oral and systemic exposure to BPA from resin-based dental restorative materials over time.
