ABSTRACT
Afterwards, many further isotropic models have followed (Huiskes et al. 1987, Carter et al. 1989, Beaupré et al. 1990a). These models, which were developed to predict the trabecular architecture, were initially based on the hypothesis that cancellous bone is a self-optimizing biological material seeking to maximize its own structural design (Huiskes et al. 1987, Pettermann et al. 1997, Prendergast 1997). These isotropic models considered the local Strain-Energy Density (SED) as an objective remodelling function. Thus, the relationship between the bone mass and the local strain values in the bone tissue was obtained with the minimization of the SED.
