ABSTRACT
The search for better cancer treatments is ongoing and research largely falls into two categories; the design of novel tumor-specific molecular targets using genomics and proteomics research and improving drug delivery and tumor targeting. Nanosized medicines are more like new chemical entities than conventional drug delivery systems or formulations, which simply entrap, solubilize, or control drug release without resorting to chemical conjugation. Additionally, immobilization of the biorecognition species must be achieved while maintaining its bioactivity. The utility of bioresponsive hydrogels is vividly apparent in their applications. These hydro-gels have been used in tissue engineering in mediated drug delivery and biosensing applications. Bioresponsive hydrogels have improved and forged new applications in a variety of fields; however, to continue their advancement a fundamental design concept is required in the information flow scheme. The design of bioresponsive hydrogels seeks to unite the conferred capacity for biorecognition of bioreceptor with the capacity for tailored response using unique macromolecular structures and architectures of the hydrogels.
