ABSTRACT
The present investigation was aimed to discover the lead compound from P. sativum seed for cancer treatment. Molecular docking studies were performed for the isolated compound against cancer target, Heat Shock Protein (Hsp 90). Preliminary phytochemical tests confirm the presence of flavonoids. GC-MS profile showed the occurrence of 11 compounds in the seeds of P. sativum. Among these, flavone was selected as ligand for docking studies. Docking study showed that the ligand flavone was strongly bound with target Hsp 90 with low binding energy. Thus, the flavone isolated from P. sativum is an emerging lead for the process of bringing a new cancer drug.
