ABSTRACT
Cancer is a disease in which cells uncontrollably divide, destroying body tissue. Sometimes, it is regarded as a group of diseases that involves abnormal cell growth with the potential to spread to other body parts. Drug development involves the optimization of a new or existing pharmaceutical agent identified from drug discovery. This process begins from studying disease weaknesses and strengths with the aim of finding a way to reverse or stop its mechanistic strengths on body cells. Critical to an effective drug development process are drug properties which include lipophilicity, solubility, PKa, and permeability. These properties inform the developers of how they should manipulate the drug molecules through structural-activity-relationships (SARs) studies to make them as least toxic and most effective 30as possible. Before getting to the market, the properties guide formulation and their effects are monitored through different stages of clinical trials.
