ABSTRACT
The increased hydrophilicity of Phenylboronic acid (PBA)-containing materials induces the release of the payload due to the enhanced permeability or disintegration of the PBA-based platforms. Glucose-sensitive films have attracted attention for the construction of self-regulated drug delivery systems. The Layer-by-layer (LbL) films are suited for drug delivery system with controlled composition, thickness, size, and shape. PBA-modified LbL films and microcapsules have successfully been used in the development of self-regulated insulin delivery systems. Glucose-sensitive platforms based on poly(acrylic acid)s were widely adopted to design self-regulated drug delivery systems. The biocompatible glucose-responsive complex micelle provides a new avenue to build up the self-regulated drug delivery system. Polysaccharides are highly attractive in terms of drug delivery due to many favorable characteristics, such as low toxicity, biocompatibility, stability, and hydrophilic nature. Polymer micelles and vesicles have much interest as nanosized platforms for glucose-sensitive drug delivery due to the excellent properties, such as prolonged circulation time, enhanced stability, and higher safety.
