ABSTRACT
The trace element selenium (Se) is crucial for the biosynthesis of selenoproteins. Both neurodevelopment and the survival of neurons that are subject to stress depend on a regular selenoprotein biosynthesis and sufficient Se supply by selenoprotein P. Serum analyses of cytokines, chemokines, growth factors, and trace elements may mirror neuroregenerative processes during recovery. High normal Se levels may contribute to a positive outcome after traumatic spinal cord injury (TSCI). TSCI is a devastating and life-changing event that affects both the local site of injury and the entire body. TSCI causes severe medical, psychological, social, and economic challenges for concerned patients, their families, and the health care system. Next to hormones, certain trace elements are involved in developmental and regenerative processes. The group of selenocysteine-containing selenoproteins contributes to protecting cells from oxidative damage, primarily via the families of Se-dependent glutathione peroxidases and thioredoxin reductases.
