Co-morbidity is the presence of multiple physical, psychiatric, and social symptoms in a patient. Co-morbidity is common, increasingly prevalent, and poses difficulties in treatment. This chapter encourages clinicians to move away from a focus on myriad individual symptoms in favor of a more holistic, behavior-oriented approach. Concepts from cognitive behavior therapy are adapted to the brief clinical interview in a way that helps clinicians reframe challenging patient encounters. Patients with a history of trauma or other severe psychiatric illnesses can still benefit from this technique albeit with adaptations by the clinician.