ABSTRACT
The role of progestogens in supporting early pregnancy in women with unexplained recurrent pregnancy loss has always been controversial and always stirs up debate. Serum progesterone levels of women were checked on the day of positive urine pregnancy test and repeated 48 hours later. The primary objective of the trial was to study the improvement of pregnancy rate, confirmed by the presence of fetal heartbeat at 12 weeks’ gestation, determined by transvaginal ultrasound. The meta-analysis concluded that administration of progestogens early in pregnancy to women with recurrent miscarriages may lower the miscarriage rate from 26.3% to 19.4%. Treatment was started immediately after documentation of ovulation using ultrasound through luteal phase until confirmation of pregnancy and continued until 28 weeks. The primary objective of the trial was to study the improvement of pregnancy rate, confirmed by the presence of fetal heartbeat at 12 weeks’ gestation, determined by transvaginal ultrasound.
