This article examines the effects of categorizing certain groups of people as “other” and according them a lower moral status. It is easier to justify draconian laws and policies if the boundary of us versus them is solidly in place, particularly if it is global in scope. I will focus on four groups: detainees, refugees, “enemy” women, and gays. They tend to be treated as expendable, socially inferior, aberrant or alien, and undeserving. The costs of marginalization raise both ethical and human rights concerns. I will look at the linguistic, conceptual, and ethical levels and offer some recommendations.