ABSTRACT

The deposition of protein at the solid-aqueous solution interface is of widespread occurrence and is a problem, for example, in the fouling of food processing plant equipment, the deposition of blood proteins onto cardiovascular implants, and in biomedical separations such as the isolation of individual proteins from mixtures using ceramic membranes. A different strand of interest on protein deposition comes from biosensor development and tissue engineering, where protein deposition is desired. In these applications the adsorption kinetics and the biophysical state of the adsorbed protein are likely to dictate the subsequent cellular and tissue responses.