ABSTRACT
INTRODUCTION The idea of injecting fillers into the subcutaneous tissues has been entertained since the earliest days of modern aesthetic surgery. In 1911, Fredrick Kolle [1] created a detailed classification of deformities of the forehead, nose, mouth, cheek, chin, neck, and body for the purpose of systematizing subcutaneous injections of paraffin into humans. As injecting paraffin fell out of favor, aesthetic surgeons continued using the injection technique to inject other substances. Charles Conrad Miller described his experiences with infiltration of fat tissue through cannulas in 1926 [2]. Even though Miller reported good results with the injected fat, the technique he described never became popular. With the introduction of liposuction in the 1980s, physicians renewed their interest in the grafting of autologous fat through a cannula [3-6].
