ABSTRACT

Rasmussen’s syndrome (RS) is a chronic encephalitis that leads to a progressive unilateral seizure disorder, functional decline, and hemiplegia. Although Rasmussen and colleagues originally described this syndrome in 1958 in the context of possible viral encephalitis, similar to Kozhevnikov’s epilepsy (tick-borne encephalitis with a similar scenario of epilepsia partialis continua), no consistent viral etiology has ever been identified. It is currently believed to be an autoimmune disease, based both on the pathology that has been elucidated and response to therapy.