ABSTRACT
Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a lymphoproliferative disease originating and presenting primarily in the subcutaneous fat tissue, displaying various phenotypic variants.
CLINICAL FEATURES
The disease presents with multiple indurated plaques or tumors predominantly located on the lower legs and to a lesser extent the trunk (1-3). The neoplastic infiltrates simulate panniculitis. The skin lesions may ulcerate (Fig. 1). Systemic features such as fever, malaise, fatigue, myalgias, chills and weight loss are not uncommon. Some patients develop a hemophagocytic syndrome with resultant cytopenia which may be in part due to release of cytokines, particularly TNFalpha and IFNgamma (4). Mostly patients in their fifth decade are affected. There is no gender predilection.
HISTOLOGY
