ABSTRACT
The creation and analysis of genetically modified mice is currently the most commonly used approach to investigate the role of specific genetic alterations in the causation of mental retardation (MR) and to model the pathogenesis of the abnormalities that result (reviewed in Refs. 1-5). In addition to providing insight into the aberrations that lead to alterations in brain development and function, the investigation of disorders in genetically modified mice also advances our
knowledge of the roles that selected genes play in regulating normal aspects of learning and memory.
