ABSTRACT
During the last two decades invasive fungal infections (IFIs) have emerged as important medical problems, particularly among immunocompromised patients. This trend is alarming problems, IFIs are associated with significant morbidity and high mortality, which in some cases may exceed 90% (1,2). While endemic fungi may also cause infections in immunocompromised patients in certain areas of the world, opportunistic fungi are by far the most important causes of IFIs in these patients worldwide. While infections due to Candida spp. remain an important problem in immunocompromised patients, infections due to filamentous fungi have become progressively more frequent and retain their extremely high mortality in susceptible patients (2,3). It is especially against these refractory infections that host defenses and immune reconstitution are very important in order to improve their dismal outcome.
