ABSTRACT
Single-pot processing was developed to provide the means for mixing, granulating, drying, and blending pharmaceutical granulations in a single apparatus. Although equipment design varies from manufacturer to manufacturer (Figs. 1-3), this category of processors consists of a high-or low-shear mixer-granulator (similar to conventional granulators) and outfitted with a variety of drying options. Initially, vacuum was combined with a heat-jacketed bowl to provide the means for drying in the single pot. Today, processors are available that provide vacuum drying with microwaves or that percolate gas under low pressure into the vacuum chamber (i.e., processing bowl). Another very interesting improvement is the use of swinging processing bowls (1).
