ABSTRACT
Melt granulation and melt pelletization are agglomeration processes that have gathered increasing interest in the pharmaceutical industry for the concept of utilizing a molten liquid as a binder. Unlike the conventional use of aqueous or organic solvents as binders, the binding liquid in melt processes remains as a constituent of the formulation. However, the basic principles in melt agglomeration processes are relatively similar to those of wet agglomeration processes with solvents except that the interpretation of the melt agglomeration processes is not complicated by an evaporation of the molten binding liquid.
