ABSTRACT
Hereditary disorders of myelin formation or its maintenance comprise the ‘‘leukodystrophies,’’ a term derived from leuko ‘‘white’’ and dystroph ‘‘defective nutrition’’ (1). These disorders are characterized based on biological and pathologic features rather than a common clinical syndrome. We will apply the term to monogenic disorders primarily affecting myelin formation or its upkeep, although the nosology of leukodystrophies is more complex (2).
