ABSTRACT
It has become evident that protein-protein interactions play a central role in signal transduction, and are thus key regulators of cell function. It has also become clear that the identification of therapeutically important protein-protein interactions from among the thousands of contenders requires rapid and robust screening methodologies. Fortunately, the display of naı¨ve peptide libraries on phage has proven an effective tool for the exploration of binding surfaces and the discovery of novel binding partners (1). The
utility of phage display is demonstrated by the repeated success of phage sorting in yielding potent binders against proteins for which other methods fail to discover specific ligands.
