ABSTRACT
The equilibrium solubility of a compound is defined as the maximum quantity of that substance which can be completely dissolved in a given amount of solvent. This quantity is of prime importance in many areas of pharmaceutical research, since the solubility of a potential drug substance can be the controlling factor in determining the bioavailability of that compound. As a result, studies of solubility phenomena assume a particularly important role in the preformulation aspect of drug development, and the degree of aqueous solubility, in particular, can be the defining quantity that kills a development program, alters its course, or provides a green light for continued development.
