ABSTRACT
The structural development of human skin has been intensely studied and documented, first at the light microscopy level, then at the electron microscopy level (reviewed). These early observations have now been correlated with molecular localization data, primarily using immunohistochemical techniques. The outcome has been an extremely well-defined analysis of the structural development of the human skin, which underpins the analysis of cutaneous disease. This structural framework can be used to incorporate the floodof newdata fromgenomeprojects, expression analyses usingmicroarrays, and an abundance of functional data from animal models.
