ABSTRACT

In general, this approach to classification persists to the present day; clinical diagnosis is still very much based on the morphology of individual lesions, together with the distribution and time course. Experienced clinicians can frequently make diagnoses rapidly on the basis of pattern recognition, and to a novice, this process

can appear very intuitive. It is, however, very similar to experienced garage mechanics making diagnoses based on evidence that is no more than “listening to the engine.” An exception to this is the immunocompromised patient, in which classical morphology is often disrupted.