ABSTRACT
The adsorption of proteins onto polymeric filters is of considerable practical interest. The
technique of preparing new drugs by way of fermentation processes includes their
downstream purification by separation procedures such as filtration or liquid-solid
chromatography. Separation of the extracellular products from the cell remnants is achieved
by filtration in a clarification step; microporous membranes are employed. The debris is
retained by the filter; the effluent contains the desired proteins. Ultrafiltration by way of
tangential flow operations is a technique often used to concentrate the sought-after products.
Alternatively, liquid-solid chromatography is utilized to bond the proteinaceous products to a
carrier surface. Subsequently, the desired (protein) product is released in purer form.
