ABSTRACT
Adhesion between a polymer and the surface of a solid is a major prerequisite for the film coating of pharmaceutical dosage forms (1-3). Loss of adhesion may lead to an accumulation of moisture at the film-tablet interface, potentially affecting the stability of drugs susceptible to hydrolytic degradation (4). Poor adhesion may also compromise the mechanical protection that the coating provides to the substrate (5). In addition, experiments on adhesion are useful to the pharmaceutical scientist during formulation development to investigate the relationship between tablet excipients and polymeric film-coating formulations (6).
