ABSTRACT
The preparation techniques of liposomes were classified broadly into several categories according to the basic modes of dispersion, e.g., mechanical dispersion, detergent solubilization, and solvent dispersion (1). Further research to improve the techniques was anticipated to encapsulate sufficient amounts of materials stably and in a reproducible fashion with the possibility of application on an industrial scale, in order to use the liposomes as delivery tools of therapeutic agents. We have explored various new techniques of liposomal preparation. In our extensive research of colloidal formulations for therapeutic agents, we took unique approaches in applying colloidal techniques used for the preparation of microparticulate carriers other than liposomes, e.g., microcapsules or lipid emulsions.
