ABSTRACT
Flavonoids contained in lemon have beneficial effects in modulating lipid profile and obesity. This study aimed to determine the chronic effects of aqueous fraction of lemon administration on body weight and visceral fat mass of old mice fed by a high-fat diet. Twenty-six female mice were divided into 5 groups, group 1 (K1) were fed by high-fat diet (PTL); group 2 (K2) were fed by standard diet; and three other groups were fed by PTL and got aqueous fraction of lemon with 3 different doses, 0.20 g/kgBB (K3), 0.40 g/kgBB (K4), and 0.80 g/kgBB (K5) for 75 days. Initial body weight, final body weight, and visceral fat mass were measured. The results showed that the final weight and visceral fat mass of K3 were significantly lower among the groups (p<0.05). Therefore, chronic administration of lemon aqueous fraction, in a dose-dependent manner, has the potential to reduce visceral fat.
