ABSTRACT

The recognition that diet and nutrition play a significant role in the metabolism of exogenous (foreign) and endogenous compounds has received attention in recent years (1). Current data suggest that the nutritional state—nutrient excess and imbalances—has an influence on the metabolism of a variety of these substances. Indeed, progress has also been made in recent years in the understanding of the relationship between dietary fat and the metabolism of foreign compounds (environmental contaminants, xenobiotics, drugs and potential carcinogens, and cocarcinogens).