chapter  2
51 Pages

Effects of Nutrition on Transcriptional and Translational Controls of Protein Synthesis in Liver

WithChallakonda Ν. Murty

The liver, being the first organ to receive nutrients from the gastrointestinal tract, plays a vital role in the metabolism of ingested dietary components. Furthermore, liver cells are actively involved in synthesizing many proteins including an extensive array of enzymes involved in drug metabolism. Also, the liver manufactures most of the plasma proteins. In relation to the important role that the liver plays, it is readily vulnerable to the ingestion of deficient or imbalanced diets and to toxic agents, which may alter its protein metabolism. Disturbances in protein metabolism may rapidly induce pathological changes in the liver and this subject has been the topic of many reviews and symposia (1-8).