chapter  13
32 Pages

Role of Cytokines in Feline Retrovirus Diseases and Treatment

WithMary B. Tompkins, Wayne A. F. Tompkins

Cats are susceptible to infection by three subfamilies of retroviruses including: feline leukemia virus (FeLV), a member of the Oncornaviridae subfamily, feline spuma virus (FeSV), a member of the Spumaviridae subfamily, and feline immunodeficiency virus (FIV), a member of the Lentiviridae subfamily. While FeLV and FIV belong to different subfamilies and have marked differences in pathogenesis, both viruses are capable of inducing an immunodeficiency syndrome and, as such, have considerable utility as animal models for human HIV pathogenesis and therapeutic studies.