chapter  2
30 Pages


WithJames A. Lederer, Charles J. Czuprynski

This chapter will not attempt to review in detail the voluminous literature on the molecular and biological aspects of interleukin-1 (IL-1). For that purpose, the reader is referred elsewhere for excellent reviews of the subject (1-5). Instead, we will focus on two broad areas of emphasis: first, a description of the IL-1 family of peptides, their receptors, and their biological activities that are related to host defense; second, an overview of the production of IL-1 and its biological activities in species of veterinary importance.