chapter  7
16 Pages

Hematopoietic Microenvironments

WithMichael W. Long

Hematopoietic development is regulated by a complex set of events in which cells interact with each other, with general and specific growth factors, and with the surrounding extracellular matrix (ECM; 1). These interactions are important for a variety of reasons, such as localizing cells within the microenvironment, directing cellular migration, and initiating growth factor-mediated developmental programs. However, simple interactions, such as those between cells and growth factors, are not the only interactions by which developing cells are regulated. Further complexity occurs through interactions of cells and growth factors with the extracellular matrix, or by combined interactions that generate a specific developmental responses.