chapter  10
13 Pages

Eosinophil Interactions with Extracellular Matrix Proteins

Effects on Eosinophil Function and Cytokine Production
WithGarry M. Walsh, Andrew J. Wardlaw

Tissue infiltration by often large numbers of eosinophils is one of the consistent features of asthma and related diseases such as allergic rhinitis or atopic dermatitis (1,2). The ability of eosinophils to generate an array of pro-inflammatory mediators, in particular the cytotoxic granule proteins such as eosinophil major basic protein (MBP), has led to the hypothesis that asthma is an ongoing mucosal inflammatory disease, a major component of which is the tissue damage mediated by eosinophil-derived mediators (3,4). The mechanisms responsible for selective eosinophil accumulation in the airways in asthma are complex but probably involve a combination of selective adhesion to bronchial postcapillary venular endothelium, followed by transmigration into the bronchial submucosa under the influence of chemotactic factors such as platelet-activating factor (PAF), leukotriene B4, and C-C chemokines such as regulated on activation, normal T cell expressed and secreted (RANTES) (5,6).