chapter  12
29 Pages

Regulation of Eosinophil Mediator Release by Adhesion Molecules

WithHirohito Kita

At present, eosinophils are recognized as pro-inflammatory cells and likely play a major role in allergic diseases, such as bronchial asthma and atopic dermatitis. The eosinophil is an important source of cytotoxic proteins, lipid mediators, and oxygen metabolites, which have the potential to induce pathology in disease. Recent studies on cell adhesion molecules suggest that in addition to adhesive interactions, adhesion molecules modulate intracellular signaling pathways and regulate effector functions of the cells. The purpose of this chapter is to discuss the potential roles of adhesion molecules as regulators of mediator release from eosinophils.