chapter  15
18 Pages

Adhesion Pathways Controlling Recruitment Responses of Lymphocytes During Allergic Inflammatory Reactions In Vivo

WithDonald Y. M. Leung, Louis J. Picker

Chronic allergic diseases such as atopic dermatitis (AD), allergic rhinitis, and asthma are associated with organ-specific infiltration of T helper type 2 (Th2)-like T cells expressing interleukin (IL)-4, IL-5, and IL-13 genes (1,2). These memory T cells play an important role in the induction of local allergen-specific IgE responses and the recruitment of eosinophils into the bronchial airways of asthmatics, the nasal mucosa of patients with allergic rhinitis, or the skin lesions of patients with AD. The potential mechanisms that control recruitment of T lymphocytes to different tissue sites in particular allergic diseases are therefore of considerable interest.