ABSTRACT
The acute phase response to injury and infection is a carefully orchestrated series of systemic and local changes intended to restore homeostasis. Systemic changes include fever and an increase in the concentration of leukocytes in the blood. Thiostatin cDNAs were independently cloned from liver cDNA libraries prepared from Buffalo, Wistar, and Sprague-Dawley rats. There are two distinct thiostatin mRNAs which are 96% identical at the nucleotide level. Thiostatin and related genes have been isolated by a number of groups. Two different thiostatin genes, one kininogen gene, and one structurally related pseudogene were obtained by Fung and Schreiber. Thiostatin mRNA also has a relatively long half-life compared to other acute phase protein genes.
